8-Hydroxydeoxyquanosine as apotential tumer marker for diagnosis of prostate cancer and its association with Prostatic Specific Antigen

Abstract

Prostate cancer (PCa) is one of the malignancies that affects men and significantly contributes to increased mortality rates in men globally.8 Hydroxydeoxyquanosine (8OHdG) is one of the predominant forms of free radical-induced oxidative lesions and has therefore been widely used as a biomarker for oxidative stress and carcinogenesis. Prostate Specific Antigen (PSA) is a tumor marker for prostate cancer. PSA is an enzyme produced by the prostate gland and is detected in the blood under normal conditions. Objective Evaluation of serum 8OHdG as Tumer marker of prostate cancer and its relationship with PSA. Method This case- control study was carried out at Department of Biochemistry, College of Medicine, University of Baghdad and at Urology department, Ghazi Al-Hariri Hospital for surgical specialty during the period from March 2022 to May 2023. It included 120 men patients, 60 men patients who diagnosed to have prostate cancer ,and 60 men were apparently healthy men. Investigations included serum measurements of 8OHdG by using enzyme linked immunosorbent assay (ELISA) technique and also measurement of serum PSA. Results The results of the present study showed that there was a significant difference in 8OHdG in prostate cancer patients as compared with the control group. The results also showed that the S.PSA were higher in the patients group compared to the controls group with significant statistical difference. Conclusion According to the results obtained we can be concluded that higher levels of 8OHdG and PSA may be associated with risk of prostate cancer.